MODERN TRENDS IN HUMAN LEUKEMIA AND CANCER

 

XVIII. Wilsede Meeting

June 19 -23, 2010

 

Saturday (19th)

8:00 – 15:00 Registration at Heinrich-Pette-Institut (Hamburg)

Transportation to Undeloh/Niederhaverbek/Wilsede

14:00 Registration at Emhof, Wilsede

16:00 Welcome Address – Axel Zander

16:10 – 16:50 Special Lecture

Hugo Snippert (Utrecht)

"Epidermal and intestinal stem cells: Molecular and cellular controls of self renewal"

 

17:00 Session I: Stem Cell Ontogeny and its Niche

Chairs: D. Williams (Boston) and A. Zander (Hamburg)

17:05 – 17:30 Alexander Medvinsky (Edinburgh)

Hierarchical organisation of the developing HSC lineage in the AGM region

17:30 – 17:55 Georges Lacaud (Manchester)

Haematopoietic cells are generated from a haemogenic endothelium through a Runx1 dependent process

17:55 – 18:20 Toshio Suda (Tokyo)

                                     Hematopoietic Stem Cells in Hypoxic Niche

18:20 – 18:45 David A Williams (Boston)

Rho GTPases in normal and leukemia stem cell niche function

 

19:30 Reception and Dinner

Wilseder Hof

 

Sunday (20th)

9:00 Session II: Cancer Immunotherapy and Prognostics

Chairs: N. Kröger (Hamburg) and G. Riethmüller (Munich)

9:00 – 9:25 Hans-Jochem Kolb (Münich)

Mechanism of graft-versus-leukemia effects

9:25 – 9:50 Nicolaus Kröger (Hamburg)

Adoptive immunotherapy with donor lymphocyte infusion targeting JAK2-V617F-positive HSC in patients with myelofibrosis following allogeneic stem cell transplantation

9:50 – 10:15 Els Goulmy (Leiden)

Immunization by and immunotherapy with haematopoietic restricted minor Histocompatibility antigens

10:15 – 10:45 coffee break

10:45 – 11:10 Ton Schumacher (Amsterdam)

Dissection of antigen-specific T cell immunity with self-destructive peptides and combinatorial codes

11:10 – 11:35 Evren Alici (Stockholm)

Strategies to restore natural killer cell activity in hematological malignancies

11:35 – 11:50 Ellen Preuß (Frankfurt)

                                     TK.007 is a promising suicide gene for adoptive immunotherapy and cancer gene therapy

 

11:50 – 12:15 Stefan Balabanov (Hamburg)

Proteome analysis as a tool for identification of novel therapeutical targets in leukemia and cancer

 

12:15 – 12:40 Claudia Baldus (Berlin)

Prognostic and biologic significance of molecular markers in acute leukemia

12:40 – 14:00 Lunch (Heidemuseum) & Poster viewing

 

14:00 Session III: Transcriptional Control of Cell Fate Chairs: K. Welte (Hannover) and C. Bonifer (Leeds)

 

14:00 – 14:25 Ingo Roeder (Dresden)

Individual clone dynamics and the effect of clonal heterogeneity - Lessons from a mathematical model analysis

14:25 – 14:50 Daniel G. Tenen

Regulation of normal and leukemic stem cells by myeloid transcription factors

14:50 – 15:15 Bertie Göttgens (Cambridge)

Genome-wide analysis of transcriptional control in normal and leukaemic blood stem/progenitor cells

15:15 – 15:45 coffee break

15:45 – 16:10 Amanda Fisher (London)

Resetting the lineage clock – how does reprogramming work?

16:10 – 16:25 Jörg Schönheit

A novel enhancer of the transcription factor IRF8 gene controls initial diversification of phagocyte lineages

16:25 – 16:50 Daniel Mertens (Ulm)

13q14: MiRs and more

17:00 – 19:00 Poster Session [authors present]

Poster Abstracts A - D

19:00 Dinner and Music in Emhof

Monday (21^st)

9:00 Session IV: Stem Cell Regulation and Therapy

Chairs: R. Küppers (Essen) and R. Hehlmann (Mannheim)

9:00 – 9:25 Tsvee Lapidot (Rehovot)

Dynamic interactions between the nervous and immune systems with the microenvironment regulate normal and leukemic human stem cells

9:25 – 9:50 Cynthia E. Dunbar (Bethesda)

Functional significance of the interaction between hematopoietic stem and progenitor cells and osteoblasts via a specific polarized membrane domain

9:50 – 10:15 Paul Frenette (New York)

                                    Neural regulation of the stem cell niche

10:15 – 10:40 Marina Konopleva (Houston)

Therapeutic targeting of microenvironmental interactions in leukemia

10:40 – 11:00 coffee break

11:00 – 11:25 James Mulloy (Cincinnati)

                                    Novel model for therapeutic targeting of leukemia stem cells

11:25 – 11:50 Connie Eaves (Vancouver)

                                    Regulation of CML stem cell expansion

11:50 – 12:05 Mirle Schemionek (Münster)

Metastasis suppressor 1 is a new tumor suppressor in leukemic stem cells of chronic myeloid leukemia

12:05 – 12:30 Michael Andreeff (Houston)

Multipotent mesenchymal stromal cells (MSC) in the tumor microenvironment: biology and targeting

12:30 – 12:45 Ralf Küppers (Essen)

Opportunities for Young Scientists and Clinicians

Förderungsprogamme der Deutsche Krebshilfe

12:30 – 14:00 Lunch (Heidemuseum) & Poster viewing

14:00 – 16:00 Poster Session [authors present]

Poster Abstracts E - H

16:00 – 16:30 coffee break

16:30 Session V: Gene Therapy

Chairs: C. Baum (Hannover) and C. Dunbar (Bethesda)

16:30 – 16:55 Adrian Thrasher (London)

Gene therapy for inherited immunodeficiency: successes and future prospects

16:55 – 17:20 Manuel Grez (Frankfurt)

Gene therapy for Chronic Granulomatous Disease: Ups and Downs

17:20 – 17:45 Boris Fehse (Hamburg)

LeGO vectors – colourful building blocks for multiple applications in cell biology studies

 

17:45 - 18:10 Dorothee von Laer (Innsbruck)

LCMV-pseudotyped VSV-based systems for treatment of malignant glioma

18:10 – 18:35 Hans Stauss (London)

Generation of antigen-specific naïve, effector and memory T cell populations by TCR gene transfer

18:35 – 19:00 Hinrich Abken (Cologne)

Arming immune cells to fight cancer

19:00 Dinner and Music in Emhof

Tuesday (22^nd)

9:00 Session VI: Epigenetics and MicroRNAs in Cancer and Metastasis

Chairs: H. Kalthoff (Kiel) and H. Beug (Heidelberg)

9:00 – 9:30 Michael F Clarke (Palo Alto)

                                   Regulation of self renewal in normal stem cells & cancer

9:30 – 9:55 Thomas Brabletz (Freiburg)

Tumor invasion and metastasis: EMT and cancer stem cells

9:55 – 10:20 Hartmut Beug (Vienna / Heidelberg)

                                    Annexin A1 strongly suppresses EMT and metastasis in breast cancer by strengthening epithelial polarity.

10:20 – 10:50 Coffee break

10:50 – 11:15 Adam Grundhoff (Hamburg)

miRNAs Encoded by Tumor Viruses

11:15 – 11:40 Florian Kuchenbauer Ulm)

Dissection of miRNA functions in acute myeloid leukemia in vitro and in vivo

11:40 – 12:05 Stefan Burdach (Munich)

Epigenetic maintenance of stemness in paediatric malignancy

12:05 –12:30 Constanze Bonifer (Leeds)

Dissecting the different steps in gene activation in the hematopoietic system

12:30 – 14:00 Lunch (Heidemuseum)

14:00 Session VII: Molecular Mechanisms of Leukemia

Chairs: C. Stocking (Hamburg) and R. Delwel (Rotterdam)

 

14:00 – 14:25 H. Phillip Koeffler (Singapore / Los Angeles)

Genomic Studies of Acute Lymphocytic Leukemia and PAX5

14:25 – 14:50 Shai Izraeli (Tel Aviv)

Leukemia Initiation and Progression – Lessons from Down Syndrome

14:50 – 15:05 Stefan Heinrichs (Boston)

                                     MYBL2 is a candidate tumor suppressor gene in MDS

15:05 – 15:35 Coffee break

15:35 – 16:00 Ruud Delwel (Rotterdam)

Uncovering the biology of acute myeloid leukemias

16:00 – 16:15 Philipp A. Greif (Munich)

Whole Transcriptome Sequencing allows rapid detection of mutations in acute myeloid leukemia

16:15 – 16:40 Claus Nerlov (Edinburgh)

The role of hematopoietic stem cells in C/EBPalpha mutant AML

16:40 – 16:55 Kshama Gupta (Hannover)

Hyper-activation of STAT5a is associated with LEF-1 down regulation and leukemic transformation in patients with Severe Congenital Neutropenia

16:55 – 17:20 Olivier Bernard (Paris)

TET2 mutations in human myeloid malignancies

19:00 Farewell Dinner in Heidemuseum